49ers build 28-point lead hold on for 41-33 win over Lions Nick Bosa was ready to kick back and relax while the San. Box score for the San Francisco 49ers vs Detroit Lions NFL game from September 12 2021 on ESPN. Expert recap and game analysis of the San Francisco 49ers vs Detroit Lions NFL game from September 12 2021 on ESPN. . Lions Week 1 Highlights NFL 2021 The San Francisco 49ers take on the Detroit Lions during Week 1 of the 2021 NFL season..
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