In her debut appearance in The Amazing Spider-Man No 210 Spider-Man goes to Madame Web for help rescuing a kidnapping victim and. Madame Web sets up an exciting future for Spider-Mans cinematic universe at Sony as the. Madame Web Cassandra Webb is a fictional character appearing in American comic books published by Marvel Comics. Cassandra Webb will make her Marvel debut as Madame Web in the 2024 film which will explore her origin and that of three other spider heroes. Sydney Sweeneys Julia Carpenter suit from the Madame Web trailer underwent one major change compared to her Spider-Woman comic..